After attending high school in Potenza, Vittorio Camardese moved to Rome to undertake higher studies. He graduated in medicine, specializing in radiology, then began professional medical practice at the Ospedale S. Filippo Neri in Rome, later working at the Policlinico Umberto I, also in Rome.
He evolved his musical style through teaching himself, and in amateur performances. But in 1956, he played on the RAI Italian television talent show Primo applauso, his first television appearance, in which he won first prize. The television programme Chitarra, amore mio featured him in 1965, and he was seen again in 1973 in the music-based talk show Speciale per voi.
He regularly visited two of Rome's most important jazz venues, the Music Inn and Folkstudio. Here, he joined several famous musicians in performances, including Chet Baker, Tony Scott, Joe Venuti, Lelio Luttazzi, Romano Mussolini and Irio de Paula.
In 1978 he met his partner with whom he remained for 18 years. At the time, she had a three-year-old son, Roberto Angelini, who went on to become a singer and songwriter. The same year also saw Camardese's final television appearance. His shy and modest nature, together with the pressure of performing on live television, caused him to turn down further requests for such shows.